Vista + WebEx
I was on a WebEx conference last month, and it's no secret that I've got a few computers sitting around... Yet for all my computers, I couldn't use WebEx. Why? Well, WebEx wasn't supporting Vista and doesn't support Linux and it also doesn't play overly well with OS X. I suppose I could have fought to get it working on OS X but the webinar was minutes away from starting.
This month I decided to get an early start and a couple hours before the conference I tried out Vista. It worked slightly better, instead of getting nothing, I had errors copying files when WebEx Event Manager tried to start. I fiddled for a little bit and solved my problem... If you want to use WebEx in Vista, it seems that you have to right click on IE and "Run as Administrator". I'd recommend that you don't surf other sites from this instance of IE and you pray that no WebEx vulns pop-up but that was the only way I could get the Event Manager to properly load. Just thought I'd share that tidbit.